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T2DM, CV Safety, and Efficacy: DPP-4 Inhibitors in focus

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Presentation on theme: "T2DM, CV Safety, and Efficacy: DPP-4 Inhibitors in focus"— Presentation transcript:

1 T2DM, CV Safety, and Efficacy: DPP-4 Inhibitors in focus

2 DPP-4 Inhibitor CV Outcomes Trials in T2DM

3 T2DM CV Outcomes Trials From the DPP-4 Inhibitor Class

4 SAVOR-TIMI 53: Primary Endpoint

5 SAVOR-TIMI 53: Hospitalization for HF

6 EXAMINE: Primary Endpoint

7 EXAMINE: Hospitalization for HF

8 TECOS: Study Design

9 TECOS: Effect of Sitagliptin vs Placebo on CV Outcomes in T2DM

10 TECOS: Hospitalization for HF

11 DPP-4 Inhibitors: Hypoglycemia

12 DPP-4 Inhibitors: Pancreatitis

13 Future DPP-4 CV Outcomes Trials in T2DM

14 Managing T2DM: incorporating injectable fixed-dose combinations

15 Fixed-dose Combinations

16 Why Combine Basal Insulin and GLP-1 RAs?

17 DUAL-I: HbA1c Comparison

18 DUAL-I: Percentage of Patients to Target HbA1c

19 DUAL-I: Change in Body Weight

20 DUAL-I: Confirmed Hypoglycemia

21 DUAL-I: Nausea Over 26 Weeks

22 Addition of Insulin to GLP-1 RA and Addition of GLP-1 RA to Insulin in T2DM

23 When and How Should We Use Combination Therapies?

24 T2DM, CV SAFETy, and efficacy: GLP-1 Receptor Agonists in focus

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31 ELIXA: Severe Symptomatic Hypoglycemia

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35 T2DM, CV SAFETy, and efficacy: SGLT2 Inhibitors in focus

36 EMPA-REG OUTCOME

37 EMPA-REG OUTCOME: Study Design

38 EMPA-REG OUTCOME: Effect of Empagliflozin vs Placebo on the Primary Composite Outcome

39 EMPA-REG OUTCOME: Effect of Empagliflozin vs Placebo on CV Death

40 EMPA-REG OUTCOME: Effect of Empagliflozin vs Placebo on Individual CV Endpoints

41 EMPA-REG OUTCOME: Effect of Empagliflozin vs Placebo on All-cause Mortality

42 EMPA-REG OUTCOME: Effect of Empagliflozin vs Placebo on HF Hospitalization

43 Future SGLT2 Inhibitor CV Outcomes Trials

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