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Advances in basic and clinical immunology in 2011
Javier Chinen, MD, PhD, William T. Shearer, MD, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 2, Pages (February 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 Development of induced pluripotent stem cells (iPSCs) and differentiation into different cell lineages. Fibroblasts are obtained from a skin biopsy specimen and reprogrammed into iPSCs by expressing 4 genes (OCT4, KLF4, SOX2, and cMYC) introduced by the STEMCCA lentiviral vector. Different cell lineages can be differentiated in vitro by using specific culture conditions.59 CNS, Central nervous system; GI, gastrointestinal; HSC, hematopoietic stem cell; LTR, long terminal repeat. Journal of Allergy and Clinical Immunology , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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