Presentation is loading. Please wait.

Presentation is loading. Please wait.

Tandem Modifications of an Epoxyquinone C7N Pharmacophore

Published byMorris McDonald Modified over 6 years ago

Similar presentations

Presentation on theme: "Tandem Modifications of an Epoxyquinone C7N Pharmacophore"— Presentation transcript:

1 Tandem Modifications of an Epoxyquinone C7N Pharmacophore
Linquan Bai  Chemistry & Biology  Volume 20, Issue 7, Pages (July 2013) DOI: /j.chembiol Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Figure 1 Three Families of Natural Products with Different C7N Moieties (A) Ansamycin-type natural products with 3,5-AHBA C7N moiety. (B) Aminocyclitol-type natural products with 2-epi-5-epi-valiolone as intermediate. (C) Manumycin-type natural products with epoxyquinone C7N moiety. The epoxyquinone moiety is highlighted with the square. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2013 Elsevier Ltd Terms and Conditions

Download ppt "Tandem Modifications of an Epoxyquinone C7N Pharmacophore"

Similar presentations

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.
Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,
Multifaceted roles for lipids in viral infection Nicholas S. Heaton, Glenn Randall Trends in Microbiology Volume 19, Issue 7, Pages 368-375 (July 2011)

Multifaceted roles for lipids in viral infection Nicholas S. Heaton, Glenn Randall Trends in Microbiology Volume 19, Issue 7, Pages (July 2011)
Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &
Ancient Endo-siRNA Pathways Reveal New Tricks Julie M. Claycomb Current Biology Volume 24, Issue 15, Pages R703-R715 (August 2014) DOI: 10.1016/j.cub.2014.06.009.

Ancient Endo-siRNA Pathways Reveal New Tricks Julie M. Claycomb Current Biology Volume 24, Issue 15, Pages R703-R715 (August 2014) DOI: /j.cub
Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages 180-190 (April 2010) DOI: 10.1016/j.tics.2010.01.008.

Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics
Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis Tim J. Wigle, Laurel M. Provencher, Jacqueline.

Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis Tim J. Wigle, Laurel M. Provencher, Jacqueline.
In Vivo Photoswitchable Flow Cytometry for Direct Tracking of Single Circulating Tumor Cells Dmitry A. Nedosekin, Vladislav V. Verkhusha, Alexander V.

In Vivo Photoswitchable Flow Cytometry for Direct Tracking of Single Circulating Tumor Cells Dmitry A. Nedosekin, Vladislav V. Verkhusha, Alexander V.
A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi.

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi.
Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &

Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates Bradley Croy Doak, Bj ӧ rn Over, Fabrizio Giordanetto, Jan Kihlberg.

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates Bradley Croy Doak, Bj ӧ rn Over, Fabrizio Giordanetto, Jan Kihlberg.
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.
Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.
Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.

Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.
Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,

Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,
LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions Takayuki Miki, Sho-hei Fujishima, Kazuhiro.

LDAI-Based Chemical Labeling of Intact Membrane Proteins and Its Pulse-Chase Analysis under Live Cell Conditions Takayuki Miki, Sho-hei Fujishima, Kazuhiro.
The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility Selena M. Sagan, Neda Nasheri, Christian.

The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility Selena M. Sagan, Neda Nasheri, Christian.
Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage John Tam, Greg L. Beilhartz, Anick Auger, Pulkit Gupta, Alex G. Therien,

Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage John Tam, Greg L. Beilhartz, Anick Auger, Pulkit Gupta, Alex G. Therien,
Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers George P. Tegos, Tatiana N. Demidova, Dennisse Arcila-Lopez, Haeryeon Lee,

Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers George P. Tegos, Tatiana N. Demidova, Dennisse Arcila-Lopez, Haeryeon Lee,

Similar presentations

Ads by Google