1. Rapamycin in transplantation: A review of the evidence
Richard N. Saunders, Mathew S. Metcalfe, Michael L. Nicholson 
Kidney International 
Volume 59, Issue 1, Pages 3-16 (January 2001)
DOI: /j x
Copyright © 2001 International Society of Nephrology Terms and Conditions

2. Figure 1
Proposed mechanism of action for rapamycin. Abbreviations are: mTOR, mammalian target of rapamycin; IL, interleukin. Rapa inhibits (1) Phosphorylation of 4E-BP1, preventing release of eIF-4E and initiation of translation12,13; (2) P27-mediated activation of cdk2-cyclin E and synthesis of proteins important for cell cycle progression14; and (3) p70S6 kinase activation, limiting ribosomal protein S6 phosphorylation and reducing synthesis of ribosomal/translational proteins15,16.
Kidney International  , 3-16DOI: ( /j x)
Copyright © 2001 International Society of Nephrology Terms and Conditions