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Alexander L. Fogel, BS, Sharleen Hill, MD, Joyce M.C. Teng, MD, PhD 

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Presentation on theme: "Alexander L. Fogel, BS, Sharleen Hill, MD, Joyce M.C. Teng, MD, PhD "— Presentation transcript:

1 Advances in the therapeutic use of mammalian target of rapamycin (mTOR) inhibitors in dermatology 
Alexander L. Fogel, BS, Sharleen Hill, MD, Joyce M.C. Teng, MD, PhD  Journal of the American Academy of Dermatology  Volume 72, Issue 5, Pages (May 2015) DOI: /j.jaad Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 The mammalian target of rapamycin (mTOR) pathway and therapeutic targets. Akt, Protein kinase B; AMPK, 5' AMP-activated protein kinase; eIF4B, eukaryotic translation initiation factor 4b; FLCN, folliculin; GNAQ, guanine nucleotide-binding protein G(q); mTORC, mTOR complex; NF1, neurofibromin-1; PDK1, 3-phosphoinositide -dependent protein kinase-1; PI3K, phosphoinositide 3-kinase; PKCa, protein kinase C-alpha; PTHS, PTEN hamartoma tumor syndromes; REDD1, regulated in development and DNA damage responses-1; RHEB, Ras homolog enriched in brain; Rho, Rhodopsin; S6K, S6 kinase; TSC, tuberous sclerosis comple. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Tuberous sclerosis. Facial angiofibromas.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Facial angiofibroma in a 16-year-old girl treated with topical rapamycin. A, Before treatment. B, Substantial improvement noted after 12 weeks of treatment using topical rapamycin. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Pachyonychia congenita. Plantar callouses.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

6 Fig 5 Arterial venous malformation.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

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