1. Combating Another Side of Smoke Inhalation

2. Table of Contents

3. Indication and Important Safety Information

4. Important Safety Information (cont’d)

5. Identifying Cyanide Poisoning

6. Cyanide Is an Often Overlooked Danger in Some Closed-Space Fires1

7. Difficult to Diagnose

8. When to Suspect Cyanide Poisoning

9. Mechanism of Action

10. Normal Cellular Respiration

11. How Cyanide Affects Cellular Respiration

12. How Hydroxocobalamin Interacts With Cyanide

13. How Hydroxocobalamin Interacts With Cyanide

14. CYANOKIT (hydroxocobalamin for injection) 5 g

15. Indication1

16. For Known or Suspected Cyanide Poisoning

17. Contents of Single-Vial CYANOKIT (hydroxocobalamin for injection) 5 g

18. Recommended Dosing1

19. How to Administer Single-Vial CYANOKIT (hydroxocobalamin for injection) 5 g

20. Step 1: RECONSTITUTE1

21. Step 2: MIX1

22. Step 3: INFUSE VIAL1

23. Considerations During Administration1

24. Storing and Stocking CYANOKIT (hydroxocobalamin for injection) 5 g

25. Storage of Lyophilized Form1

26. Storage of Reconstituted Drug Product1

27. Prehospital Stocking

28. Hospital Stocking

29. Grant Information

30. Grant Eligibility

31. Questions?

32. Cyanide Poisoning

33. Cyanide Poisoning

34. Indication and Important Safety Information

35. Important Safety Information (cont’d)

36. Prescribing Information for CYANOKIT(hydroxocobalamin for injection) 5 g