1. Brian Muirhead FRCPC Assistant Professor, University of Manitoba
The Efficacy and Cost-effectiveness of Fibrinogen Concentrate (FC) compared to Cryoprecipitate in major bleeding patients
Brian Muirhead FRCPC Assistant Professor, University of Manitoba

2. Objectives
Impact of higher threshold levels (1.5 versus 1.0g/L for cardiac and non-obstetrical patient) and 2.5g/L in obstetrical patients
Compare the cost of FC and cryo in the vein-to-vein process

3. Methodology
Cardiac and Obstetrical patients to receive 2 – 4gm FC or units cryo
Non-cardiac, non-obstetrical patients to receive 2gm FC or 10units cryo
40 patients in each group

5. Data Collection
Ave increase Ave TAT Ave rbc post Cryo 0.7 ( ) 69 mins* 2.5 units FC 1.3 ( ) 23 mins 0.5 units

6. NOTES
In Manitoba, cryo units are thawed by the blood bank, pooling is done by the clinical staff
Overwhelming preference by physicians for the fibrinogen concentrate
1 gram FC $399
5 units cryo $550