1. Hand(ednes)s on an old ligand
Hand(ednes)s on an old ligand.Two research groups report on different ways of modifying the Cp ligand so that Rh(III)-catalyzed C-H functionalization (A) would create preferred enantiomeric products (R and R′ are organic substituents; the star marks the product's chiral carbon).
Hand(ednes)s on an old ligand.Two research groups report on different ways of modifying the Cp ligand so that Rh(III)-catalyzed C-H functionalization (A) would create preferred enantiomeric products (R and R′ are organic substituents; the star marks the product's chiral carbon). (B) Ye and Cramer chemically synthesized a chiral Cp ligand that determined the arrangement of substrate and reactant, resulting in high enantioselectivity (Me, methyl; Ph, phenyl; and tBu, tert-butyl). (C) Hyster et al. biochemically modified Cp to create an artificial metalloenzyme. An appropriately positioned glutamate side chain within the host protein accelerated the C-H activation step, and the asymmetric environment around the metal led to stereoselective coupling (Piv, pivaloyloxy).
H Wang, F Glorius Science 2012;338:
Published by AAAS

2. Fig. 1 Conceptual design of the chiral Cpx* complexes.
B Ye, N Cramer Science 2012;338:
Published by AAAS

3. Fig. 2 Structure of the chiral Cpx*Rh(I) complexes 1a to 1f.
B Ye, N Cramer Science 2012;338:
Published by AAAS

4. Fig. 3 Postulated model for the stereochemical preference with complex 1c.
B Ye, N Cramer Science 2012;338:
Published by AAAS