1. DLC1 and Liver Cancer: The Akt Connection
Torsten Wuestefeld, Lars Zender 
Gastroenterology 
Volume 139, Issue 4, Pages (October 2010)
DOI: /j.gastro
Copyright © 2010 AGA Institute Terms and Conditions

2. Figure 1
Schematic representation of a model suggesting 2 independent tumor suppressive functions mediated by DLC1. (A) Loss of DLC1 expression through genomic deletion or promoter hypermethylation enhances hepatocarcinogenesis via increased RhoA signaling. (B) DLC1 phosphorylation by AKT can promote tumorigenesis without affecting DLC1's function as a RhoGTPase activating protein.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions