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Vimlesh Kumar, Mani Ramaswami  Neuron 

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Presentation on theme: "Vimlesh Kumar, Mani Ramaswami  Neuron "— Presentation transcript:

1 Kissing and Pinching: Synaptotagmin and Calcium Do More between Bilayers 
Vimlesh Kumar, Mani Ramaswami  Neuron  Volume 50, Issue 1, Pages 3-5 (April 2006) DOI: /j.neuron Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 A Model to Explain Two Activities of Synaptotagmin
The figure above proposes that calcium binding to Syt promotes (but may be dispensable for) activation of a lipid-modifying enzyme (Wenk and De Camilli, 2004). Lipid modification enables coat protein (e.g., AP-2) interactions with synaptic vesicle membrane, a process facilitated through a second activity of synaptotagmin. A postulate that the stage prior to the entry of coat proteins is rate determining (at least in the specific mutants examined) explains the effect of Syt-D3,4N on the rate of endocytosis. Subsequent correct assembly of a clathrin coat around synaptic vesicle proteins determines the fidelity of vesicle internalization. This assembly is compromised in Syt-KQ. For simplicity, additional and potentially contributing processes, e.g., V-SNARE/T-SNARE association and different routes of calcium entry (Kuromi et al., 2004) are not included in this model. Neuron  , 3-5DOI: ( /j.neuron ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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