1. Does CSF1R Blockade Turn into Friendly Fire?
Tim F. Greten 
Cancer Cell 
Volume 32, Issue 5, Pages (November 2017)
DOI: /j.ccell
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2. Figure 1 CSF1R Inhibition and Anti-Tumor Immunity
Shown is the effect of CSF-1, CSF1R, and CSF1R+ CXCR2 blockade on anti-tumor immunity. (A) Tumor-secreted CSF-1 leads to an accumulation of TAM imparing anti-tumor immunity. (B) CSF1R blockade depletes TAM but also causes an accumulation of PMN-MDSC due to Cxcl-1 secretion from CAF, which is dependent on CSF-1. This results again in an ineffective anti-tumor immunity. (C) Combined CSF1R and CXCR2 blockade reduces the number of TAMs and PMN-MDSC in the tumor microenvironment, leading to enhanced anti-tumor immunity.
Cancer Cell  , DOI: ( /j.ccell )
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