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Bjorn van Anrooij, MD, Joanne N. G. Oude Elberink, MD, PhD, Lambert F

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Presentation on theme: "Bjorn van Anrooij, MD, Joanne N. G. Oude Elberink, MD, PhD, Lambert F"— Presentation transcript:

1 Midostaurin in patients with indolent systemic mastocytosis: An open-label phase 2 trial 
Bjorn van Anrooij, MD, Joanne N.G. Oude Elberink, MD, PhD, Lambert F.R. Span, MD, PhD, Jan G.R. de Monchy, MD, PhD, Stefano Rosati, MD, André B. Mulder, MD, PhD, Johanna C. Kluin-Nelemans, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 142, Issue 3, Pages e7 (September 2018) DOI: /j.jaci Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Percentage change in symptom severity as measured by using the MSAF score halfway and after 24 weeks. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Serum tryptase level reduction during midostaurin treatment.
Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Patient accrual and trial profile. SSM, Smoldering systemic mastocytosis. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Symptom severity as measured by using the median MSAF score before and after 24 weeks of treatment with midostaurin: the higher the score, the more severe the symptoms. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E3 Response in mast cell (MC) infiltration markers after 24 weeks of midostaurin. Each bar represents a single patient. Methylhistamine and methylimidazole acetic acid levels were measured in morning urine samples voided on waking. SCORMA, Scoring Mastocytosis Index. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E4 Median scores per domain of the disease-specific Mastocytosis Quality-of-Life Questionnaire (MQLQ)– and the general Short Form Health Survey 36 (SF36)–related quality of life. A higher score indicates less burden. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E5 Effect of midostaurin dosage tapering on tryptase level and symptom severity during 12 months of follow-up. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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