1. Bovine glue (BioGlue) is catabolized by enzymatic reaction in the vascular dog model 
Yves Van Belleghem, MD, Ramses G Forsyth, MD, Kishan Narine, MD, Annelies Moerman, MD, Yves Taeymans, MD, PhD, Guido J Van Nooten, MD, PhD 
The Annals of Thoracic Surgery 
Volume 77, Issue 6, Pages (June 2004)
DOI: /S (03)

2. Fig 1
Angiographic control of a patent iliac anastomosis (arrow) with perfect run-off.
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3. Fig 2
Electron microscopy (×36,000 before 43% reduction). At the surface of the glue manifest enzymatic reaction of the high active granulocytes with black-dotted enzymes leaking out of the damaged cell (arrow).
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4. Fig 3
Different stadium of the total breakdown of the glue. (A) Smooth contact surface between the glue and the adjacent tissue with early granulocytes infiltration (lower right corner). (B) “Lytic” rough aspect of the contact zone with a lot of degranulated granulocytes. (C) Granulomatous inflammatory reaction around large foci of glue characterized by infiltration of macrophages, lymphocytes, and plasma cells. (D) After disappearance of the glue, a perimeter of cellular connective tissue surrounded by young undifferentiated collagen, rich in fibroblast cells. (Hematoxylin & eosin, myeloperoxidase for granulocytes; ×100 before 53% reduction.)
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5. Fig 4
Vessel wall junction. The glue disappeared over time and was replaced by scar tissue (healing by secundam intentionam) with smooth coverage of the gap and fibroblastic infiltration without intima proliferation or reduction of the lumen. (Orcin; ×100 before 58% reduction.)
The Annals of Thoracic Surgery  , DOI: ( /S (03) )

6. Fig 5
Mass spectrometry by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the broken-down glue: a wide array of peptides with the highest densities between 16,000 and 25,000 Dalton.
The Annals of Thoracic Surgery  , DOI: ( /S (03) )