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Becker RC, et al. Lancet 2009;373:919-28

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Presentation on theme: "Becker RC, et al. Lancet 2009;373:919-28"— Presentation transcript:

1 Becker RC, et al. Lancet 2009;373:919-28

2 SCH Becker RC, et al. Lancet 2009;373:919-28

3 Study profile Becker RC, et al. Lancet 2009;373:919-28

4 Baseline characteristics and concomitant medication use
Becker RC, et al. Lancet 2009;373:919-28

5 Rate of bleeding events in the primary percutaneous coronary intervention cohort over 60 days of maintenance therapy Becker RC, et al. Lancet 2009;373:919-28

6 Major secondary efficacy outcomes for primary percutaneous coronary intervention cohort over 60 days of maintenance therapy Becker RC, et al. Lancet 2009;373:919-28

7 Rates (95% CI) of thrombolysis in myocardial infarction (TIMI) major and minor bleeding versus death or major adverse cardiac effects (MACE) Rates (95% CI) of thrombolysis in myocardial infarction (TIMI) major and minor bleeding versus death or major adverse cardiac eff ects (MACE) Thick lines are rates and thin lines are 95% CIs. The bottom shading is the 95% CI for the placebo rate of TIMI bleeding (3·3%, 95%CI 0–6·6). The top shading is the 95% CI for the placebo rate of death or MACE (8·6%, 4·0–13·2). The dark shading in the middle is the overlap of the two 95% CIs. Becker RC, et al. Lancet 2009;373:919-28

8 Safety outcomes in patients receiving study drug who subsequently needed coronary artery bypass grafting Becker RC, et al. Lancet 2009;373:919-28

9 Rate of bleeding events during 60 days of maintenance therapy in the secondary non-percutaneous coronary intervention cohort (treated medically) Becker RC, et al. Lancet 2009;373:919-28

10 Proportion of patients with at least 80% inhibition of thrombin receptor agonist peptide (TRAP)-induced platelet aggregation Becker RC, et al. Lancet 2009;373:919-28

11 Proportion of patients with at least 80% inhibition of thrombin receptor agonist peptide (TRAP)-induced platelet aggregation at 30 days and 60 days Becker RC, et al. Lancet 2009;373:919-28


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