1. Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn's Disease 
Matthias Jürgens, Jestinah M. Mahachie John, Isabelle Cleynen, Fabian Schnitzler, Herma Fidder, Wouter van Moerkercke, Vera Ballet, Maja Noman, Ilse Hoffman, Gert van Assche, Paul J. Rutgeerts, Kristel van Steen, Severine Vermeire 
Clinical Gastroenterology and Hepatology 
Volume 9, Issue 5, Pages e1 (May 2011)
DOI: /j.cgh
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2. Figure 1 Flow chart of study cohort.
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
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3. Figure 2
Early normalization of CRP level is associated with better sustained response (demonstrated by Kaplan–Meier analysis).
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
Copyright © 2011 AGA Institute Terms and Conditions

4. Figure 3
Loss of response is associated with significantly higher CRP level over time. (A) All patients with clinical relapse, P = .016; (B) patients with relapse leading to stop of therapy, P < .001.
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
Copyright © 2011 AGA Institute Terms and Conditions

5. Figure 4
CRP level at baseline and at time of first endoscopy after initiation of IFX therapy with respect to mucosal healing status (**P < .030; ***P < .001).
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
Copyright © 2011 AGA Institute Terms and Conditions

6. Figure 5
Proposed algorithm for a symptomatic patient who is a candidate for anti-TNF therapy.
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
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7. Supplementary Figure 1
Baseline CRP levels and primary clinical response.
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
Copyright © 2011 AGA Institute Terms and Conditions

8. Supplementary Figure 2
Baseline CRP and clinical relapse and subsequent need for interventions.
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
Copyright © 2011 AGA Institute Terms and Conditions

9. Supplementary Figure 3
CRP level decreases significantly after start of treatment and increases at time of relapse, however, without reaching baseline levels again.
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
Copyright © 2011 AGA Institute Terms and Conditions

10. Supplementary Figure 4
Receiver operating characteristic curve of the PPV of normal CRP (<3 mg/L) for mucosal healing.
Clinical Gastroenterology and Hepatology 2011 9, e1DOI: ( /j.cgh )
Copyright © 2011 AGA Institute Terms and Conditions