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A Seminal Finding for Understanding HIV Transmission

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Presentation on theme: "A Seminal Finding for Understanding HIV Transmission"— Presentation transcript:

1 A Seminal Finding for Understanding HIV Transmission
Nadia R. Roan, Warner C. Greene  Cell  Volume 131, Issue 6, Pages (December 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Enhancement of HIV Infection by SEVI
Prostatic acid phosphatase (PAP), an abundant protein in semen, is cleaved into the PAP peptide, which then aggregates to form amyloid fibrils termed semen-derived enhancer of viral infection (SEVI) (Münch et al., 2007). The fibrils capture HIV virions and direct them to target cells to which they fuse. Under conditions of a limiting viral inoculum, SEVI enhances infectivity of HIV virions by more than 100,000-fold Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions


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