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Published bySari Ketonen Modified over 6 years ago
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A Seminal Finding for Understanding HIV Transmission
Nadia R. Roan, Warner C. Greene Cell Volume 131, Issue 6, Pages (December 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions
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Figure 1 Enhancement of HIV Infection by SEVI
Prostatic acid phosphatase (PAP), an abundant protein in semen, is cleaved into the PAP peptide, which then aggregates to form amyloid fibrils termed semen-derived enhancer of viral infection (SEVI) (Münch et al., 2007). The fibrils capture HIV virions and direct them to target cells to which they fuse. Under conditions of a limiting viral inoculum, SEVI enhances infectivity of HIV virions by more than 100,000-fold Cell , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions
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