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Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease  Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,

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Presentation on theme: "Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease  Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD,"— Presentation transcript:

1 Analysis of basophil activation in patients with aspirin-exacerbated respiratory disease 
Chihiro Mitsui, MD, Keiichi Kajiwara, BSc, Emiko Ono, MD, PhD, Kentaro Watai, MD, Hiroaki Hayashi, MD, Yosuke Kamide, MD, PhD, Yuma Fukutomi, MD, PhD, Kiyoshi Sekiya, MD, Takahiro Tsuburai, MD, PhD, Kazuhiko Yamamoto, MD, PhD, Masami Taniguchi, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 4, Pages e8 (October 2017) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Comparison of the expression level of CD203c on basophils from 21 patients with AERD, 22 patients with ATA, and 11 HCs under stable condition. Spontaneous (A), anti-IgE–stimulated (B), and IL-3–stimulated (C) expression levels are presented. The data are expressed as the net MFI. The error bars indicate the SD. HC, Healthy control. *P < .05 and ***P < .001. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 The aspirin challenge test results. A and E, The basophil count in blood. B-D and F-H, The expression levels of CD203c on peripheral basophils in 12 patients with AERD and 7 patients with ATA. The data are expressed as the net MFI (median [interquartile]). The P values indicate comparisons relative to baseline. *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Correlation analyses between spontaneous and anti-IgE–stimulated CD203c expressions (A-C), between spontaneous and IL-3–stimulated CD203c expressions (D-F), and between anti-IgE–stimulated and IL-3–stimulated CD203c expression (G-I). HC, Healthy control. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Aspirin challenge test results (dot plots). A, The basophil count in blood. B-D, The expression levels of CD203c on peripheral basophils. The P values are for comparisons relative to baseline. *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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