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Interleukin-17: Why the Worms Squirm

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Presentation on theme: "Interleukin-17: Why the Worms Squirm"— Presentation transcript:

1 Interleukin-17: Why the Worms Squirm
Noah J. Silverstein, Jun R. Huh  Immunity  Volume 46, Issue 3, Pages (March 2017) DOI: /j.immuni Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 The IL-17 Ortholog ILC-17.1 Modulates Neuronal Activity in RMG Interneurons Chen et al. (2017) demonstrate that the C. elegans IL-17 ortholog ILC-17.1 signals via a heterodimer of two IL-17R orthologs (ILCR-1 and ILCR-2) on RMG interneurons to produce increased neuronal activity in response to input from O2-sensing neurons exposed to 21% O2. RMG interneuron activation in npr-1-null worms leads to increased velocity of movement and to increased aggregation behavior. Immunity  , DOI: ( /j.immuni ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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