1. Ten Key Trials in Cardiovascular Surgery
Gavin Murphy
On behalf of the Academic and Research Committee of the Society for Cardiothoracic Surgery in Great Britain and Ireland
28th September 2018

2. CTSN Publications

3. Patients recruited to multicentre trials in cardiac surgical patients in the UK between 2007 and 2017
Data from published trial reports

4. Strategy for Academic Cardiothoracic Surgery
Academic and Research Committee,
RCS specialty lead, 2017.
BHF Strategy Workshop, 2017
Increase in ACF/ ACL posts, 2017.
National research meeting, 2017
Change in CCT criteria by SAC 2018.
JLI research priority setting exercise,
Trainees research network, 2018.
National trials network, 2019.

5. British Heart Foundation Workshop Programme Surgical Research
Monday 13 February 2017
Co-Chairs: Professor Julian Scott (Leeds Teaching Hospitals) and
Professor Gavin Murphy (Glenfield Hospital, Leicester & BHF Chairholder)

6. James Lind Alliance ‘Believes that:
Addressing uncertainties about the effects of a treatment should become accepted as a routine part of clinical practice
Patients, carers and clinicians should work together to agree which, among those uncertainties, matter most and deserve priority attention.’

7. Aims of the Priority Setting Partnership
We are looking for the Top 10 priorities in heart surgery research
We want to hear the questions of current/previous heart surgery patients, their carers, families and friends, and healthcare professionals
If these questions are addressed by researchers, they could help with the progression of modern medicine and be to the benefit of patients

8. Initial Survey
Launched 19th March 2018 at the annual conference for the Society for Cardiothoracic Surgeons (SCTS) in Glasgow
Requests patients, carers, families and healthcare professionals to ask questions they wish to be addressed by cardiac surgery research
Closes November 2018

9. On line survey

10. Number of respondents
419 responses as of August 2018

11. Type of respondents Among healthcare professional Anaesthetist n = 77
CTS /surgeon n = 32
Intensive care n = 7
Cardiology n = 2

12. Geography by type of respondents

13. Examples of submitted questions
Area
Original questions
Submitted by
Frail patients
What is the long term benefit of complex surgery in frail patients with multiple co-morbidities?
nurse
Is there anything patients can do prior to heart surgery to help their survival rate? Does prehabilitation improve outcomes in frail patients?
doctor, others
Fluid management
Perioperative fluid management in cardiac surgery. Is fluid restriction strategy benefited to outcome?
doctor
Antiplatelet
Should all patients receive dual antiplatelet agents post CABG if no contra-indications?
Diabetic patients
Can optimising diabetic control and understanding assist in managing the cardiac disease and reduce post op complications for both staff and patients
patient
Anaesthetic agent
What is the best combination anaesthetic drugs for perioperative myocardial protection?
Point-of-care testing
Point of care testing vs clinical acumen for the outcome of delayed (ICU) bleeding.

14. Identifying uncertainties in the literature
Sources searched
Cochrane database (including Cochrane Heart group) (2010 onwards)
NICE Guidance and NICE Research recommendations database
BMJ clinical evidence
American College of Cardiology
the European Society of Cardiology
the American Heart Association
the European Association of Cardiothoracic surgeons

15. Outputs
Assimilation of literature searches and research questions to identify long-list (December 2018 to February 2019).
Second survey for long-list prioritisation (Launch SCTS March 2019).
Final prioritisation workshop moderated by JLI (NIHR) with independent observers from major funders, clinical organisations and patients groups.
Final 10 recommendations forwarded to NIHR Commissioning Board.
Collaboration with Cochrane to define knowledge gaps Autumn/Winter
Funding applications for trial portfolio 2020.

16. Twitter: @HeartSurgeryPSP
Contact details
Online survey link:

17. Thank you
Any questions?