1. NEUROCUTANEOUS MARKERS
Dr.Ashok.R.Wadhwani

2. NEUROCUTANEOUS SYNDROMES
This is a group of genetic disorders, also known as the phakomatoses,which produces a variety of developmental abnormalities that frequently involve skin, along with an increased risk of nervous system tumors. These disorders are inherited as autosomal dominant conditions .

3. Tuberous sclerosis Adenoma sebaceum. Ash leaf spots.
Subungual and gingival fibromas.
Shagreen patches.
Fibrous plaques on the forehead.

4. ADENOMA SEBACEUM:MULTIPLE ANGIFIBROMAS OF THE FACE
ADENOMA SEBACEUM:MULTIPLE ANGIFIBROMAS OF THE FACE .ERYTHEMATOUS PAPULES ON THE LOWER HALF OF FACE-CHEEKS,NASOLABIAL FOLDS,SIDES OF THE NOSE AND CHIN.

5. ADENOMA SEBACEUM

6. ASH LEAF SPOTS. Hypopigmented macules
ASH LEAF SPOTS. Hypopigmented macules. The average size is 1 to 3 cm, and the common shapes are oval, polygonal, and lance-ovate, whereas the less common shapes are dermatomal and confettilike.

7. Ash leaf spots. "confetti" macules
Ash leaf spots. "confetti" macules. Multiple, discrete, small, confetti-like, hypopigmented macules of variable size on the leg.

8. Detection of ash leaf spots may require Wood's lamp examination(UVA), especially in fair-skinned individuals. An ash leaf spot on the scalp will result in poliosis, which is a circumscribed patch of gray-white hair.

9. SUBUNGUAL FIBROMA.

10. SUBUNGUAL FIBROMA.

11. GINGIVAL FIBROMA.

12. SHAGREEN PATCH- Leathery plaques of subepidermal fibrosis,usually situated on the trunk.

13. SHAGREEN PATCH.

14. VON RECKLING-HAUSEN’S DISEASE (NF-1)
CAFÉ AU LAIT SPOTS.
AXILLARY FRECKLING.

15. CAFÉ AU LAIT SPOTS. PIGMENTED MACULES(>1 CM) ON THE TRUNK.
PLEMIFORM NEUROMA SEEN.

16. Several larger (>1.0 cm) cafe-au-lait macules on the upper chest and multiple small macules in the axillae (axillary "freckling")

17. STURGE WEBER SYNDROME
CAPILLARY HAEMANGIOMA.

18. THANK YOU