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Skin-homing and systemic T-cell subsets show higher activation in atopic dermatitis versus psoriasis
Tali Czarnowicki, MD, Dana Malajian, BA, Avner Shemer, MD, Judilyn Fuentes-Duculan, MD, Juana Gonzalez, PhD, Mayte Suárez- Fariñas, PhD, James G. Krueger, MD, PhD, Emma Guttman-Yassky, MD, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 1, Pages (July 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 ICOS, HLA-DR, and CD69 expression in CD4+ and CD8+ T-cell memory subsets in patients with AD and psoriasis. A, Higher CD4+ CLA+/CLA− ICOS expression in patients with AD compared with patients with psoriasis and controls. B, Higher CD8+ CLA+/CLA− HLA-DR expression in patients with AD compared with patients with psoriasis and controls. C, Compared with patients with AD, patients with psoriasis had significantly higher CD69 expression in CLA+ T cells. D, CD69 expression in skin-homing cells was positively correlated with PASI and negatively correlated with SCORAD. Journal of Allergy and Clinical Immunology , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 2 Skin-homing CD25+CD127−CCR4+ Treg-cell frequency and correlation with ICOS+-activated T-cell memory subsets in patients with AD and psoriasis. A, Patients with AD showed increased frequency of CD25+CD127−CCR4+CLA+ Treg cells, which correlated positively with SCORAD (B) and IgE levels (C). D and E, AD. Significant correlations were observed between CD25+CD127−CCR4+CLA+ Treg cells and CLA+ICOS+ Tcm/Tem subsets. F and G, Psoriasis. Nonsignificant correlations were observed between CD25+CD127−CCR4+CLA+ and ICOS expression in both Tcm and Tem subsets. Journal of Allergy and Clinical Immunology , DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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