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The Liver as a Hub in Thermogenesis

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Presentation on theme: "The Liver as a Hub in Thermogenesis"— Presentation transcript:

1 The Liver as a Hub in Thermogenesis
Nada A. Abumrad  Cell Metabolism  Volume 26, Issue 3, Pages (September 2017) DOI: /j.cmet Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 The Liver as a Thermogenic Hub
During cold exposure, FAs from hepatic VLDL are rapidly extracted by BAT. Adrenergic stimulation activates hepatic gluconeogenesis, providing glucose for BAT thermogenesis, and early evidence also suggests that the liver might contribute to heat generation in cold-exposed rodents. In this issue of Cell Metabolism, Simcox et al. (2017) show that FAs mobilized from cold stimulation of WAT activate HNFα in the liver, leading to increased FA oxidation and the production of acylcarnitines that serve to further fuel BAT metabolism and NST. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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