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Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid.

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Presentation on theme: "Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid."— Presentation transcript:

1 Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid Cells by Horst Dürkop, Hans-Dieter Foss, Gudrun Demel, Heike Klotzbach, Corinna Hahn, and Harald Stein Blood Volume 93(2): January 15, 1999 ©1999 by American Society of Hematology

2 Hyperplastic tonsil hybridized with a TRAF1 antisense probe (exposure, 6 weeks; original magnification × 250; original magnification of the insert × 900). Hyperplastic tonsil hybridized with a TRAF1 antisense probe (exposure, 6 weeks; original magnification × 250; original magnification of the insert × 900). Note the few faintly TRAF1+ lymphoid blasts (arrows and insert). Horst Dürkop et al. Blood 1999;93: ©1999 by American Society of Hematology

3 (A and B) Double-labeling of tonsillar tissue from patients with infectious mononucleosis with the TRAF1 (black) and EBER (red) antisense probes (exposure of autoradiography, 6 weeks; original magnifications × 350 [A] and × 150 [B]). (A and B) Double-labeling of tonsillar tissue from patients with infectious mononucleosis with the TRAF1 (black) and EBER (red) antisense probes (exposure of autoradiography, 6 weeks; original magnifications × 350 [A] and × 150 [B]). The TRAF1 probe was labeled by 35S-UTP, whereas the EBER probe was labeled by UTP-digoxigenin and detected by antidigoxin alkaline phosphatase conjugates. Horst Dürkop et al. Blood 1999;93: ©1999 by American Society of Hematology

4 Horst Dürkop et al. Blood 1999;93:617-623
©1999 by American Society of Hematology

5 Horst Dürkop et al. Blood 1999;93:617-623
©1999 by American Society of Hematology


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