1. Identification of incestuous parental relationships by SNP-based DNA microarrays 
CP Schaaf, DA Scott, J Wiszniewska, AL Beaudet 
The Lancet 
Volume 377, Issue 9765, Pages (February 2011)
DOI: /S (11)
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2. Figure
SNP-based microarray (using 620 901 markers with mean and median marker spacing of 4·7 kb and 2·7 kb, respectively) on a 3-year-old boy with multiple medical problems, indicating 668 Mb of absence of heterozygosity (shown in green blocks)
This finding is consistent with the patient being conceived as the product of a mating between first-degree relatives (coefficient of inbreeding 1/4, expected absence of heterozygosity 716 Mb). For matings between second-degree relatives (eg, uncle-niece, double first cousins), the inbreeding coefficient would be 1/8 and expected absence of heterozygosity 358 Mb.
The Lancet  , DOI: ( /S (11) )
Copyright © 2011 Elsevier Ltd Terms and Conditions