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Annexin and APS: the clot thickens

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Presentation on theme: "Annexin and APS: the clot thickens"— Presentation transcript:

1 Annexin and APS: the clot thickens
by Keith R. McCrae Blood Volume 107(11): June 1, 2006 ©2006 by American Society of Hematology

2 Model of the annexin A2–S100A10 (p11) heterotetramer, depicting binding of tPA and plasminogen (p19) leading to generation of plasmin (PLM). Model of the annexin A2–S100A10 (p11) heterotetramer, depicting binding of tPA and plasminogen (p19) leading to generation of plasmin (PLM). The anti–annexin A2 antibody (Antibody) might inhibit binding of tPA or PLG or block their interaction with each other. Illustration by A. Y. Chen; adapted from Figure 2B of Cesarman-Maus and Hajjar.5 Keith R. McCrae Blood 2006;107: ©2006 by American Society of Hematology


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