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Anti-annexin V antibodies in patients with early pregnancy loss or implantation failures
Hidehiko Matsubayashi, M.D., Ph.D.,, Tadashi Arai, M.D., Shun-ichiro Izumi, M.D., Ph.D., Toshitaka Sugi, M.D., Ph.D., John A McIntyre, Ph.D., F.R.C.Path., Tsunehisa Makino, M.D., Ph.D. Fertility and Sterility Volume 76, Issue 4, Pages (October 2001) DOI: /S (01)02009-X
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FIGURE 1 Representative data of anti-annexin V antibodies detected by ELISA. Increasing optical density values (vertical axis) were observed with increasing concentration of anti-annexin positive (open symbols) patient plasmas, but not in negative patient plasmas (closed symbols). Matsubayashi. Anti-annexin V in reproductive failure. Fertil Steril 2001. Fertility and Sterility , DOI: ( /S (01)02009-X)
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FIGURE 2 Representative data showing annexin V specificity by using anti-annexin V antibodies detected by ELISA. Decreased optical density values (vertical axis) were observed in positive patient plasmas (open symbols) after preincubation with increasing concentration of annexin V. Negative patient plasmas (closed symbols) were unaffected by identical absorption steps. Matsubayashi. Anti-annexin V in reproductive failure. Fertil Steril 2001. Fertility and Sterility , DOI: ( /S (01)02009-X)
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FIGURE 3 Distribution of anti-annexin V antibodies (optical density values, horizontal axis) in the normal population. Distribution curves for 179 healthy nonpregnant individuals tested for IgG antibody for annexin V are depicted. The data were nonparametric. If the cutoff was set at 0.23 (4 multiples of the median [MoM]) and 0.40 (7 MoM), the positive percentage of individuals are 5.0% and 1.1%, respectively. Matsubayashi. Anti-annexin V in reproductive failure. Fertil Steril 2001. Fertility and Sterility , DOI: ( /S (01)02009-X)
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