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Junk DNA Used in Cerebral Cortical Evolution

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Presentation on theme: "Junk DNA Used in Cerebral Cortical Evolution"— Presentation transcript:

1 Junk DNA Used in Cerebral Cortical Evolution
Thomas Pratt, David J. Price  Neuron  Volume 90, Issue 6, Pages (June 2016) DOI: /j.neuron Copyright © Terms and Conditions

2 Figure 1 LncND Acts as a ceRNA Sponge, Inhibiting miR-143-3p Activity, hence Elevating NOTCH Levels in Developing Cortex (A) In primate, LncND is expressed in radial glial cells (RGCs) and outer RGCs (oRGs) in the ventricular zone (VZ), inner subventricular zone (ISVZ), and outer subventricular zone (OSVZ) but not in differentiating neurons. IPC, intermediate progenitor cell; CP, cortical plate. (B) In mouse, the experimental introduction of LncND increased proportions of cells in a Pax6-expressing progenitor state. Neuron  , DOI: ( /j.neuron ) Copyright © Terms and Conditions

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