Presentation is loading. Please wait.

Presentation is loading. Please wait.

Biochemical pathways proximal to the IDH1 and IDH2 reactions.

Published byRebecca Ryan Modified over 6 years ago

Similar presentations

Presentation on theme: "Biochemical pathways proximal to the IDH1 and IDH2 reactions."— Presentation transcript:

1 Biochemical pathways proximal to the IDH1 and IDH2 reactions.
Biochemical pathways proximal to the IDH1 and IDH2 reactions. IDH1 is located in the cytoplasm and peroxisomes, whereas IDH2 is located in the mitochondrial matrix. The reactions catalyzed by these enzymes are linked to metabolites involved in amino acid metabolism, particularly that of glutamine and glutamate, and in fatty acid synthesis and the TCA cycle. IDH1 and IDH2 activities also affect the cytoplasmic and mitochondrial ratio of NADP/NADPH, a major source of reducing potential. Rob A. Cairns, and Tak W. Mak Cancer Discovery 2013;3: ©2013 by American Association for Cancer Research

Download ppt "Biochemical pathways proximal to the IDH1 and IDH2 reactions."

Similar presentations

Tricarboxylic Acid Cycle

Tricarboxylic Acid Cycle
Detoxification of ammonia and biosynthesis of urea. The basic features of nitrogen metabolism were elucidated initially in pigeons.

Detoxification of ammonia and biosynthesis of urea. The basic features of nitrogen metabolism were elucidated initially in pigeons.
KREBS CYCLE. Introduction Let us review fates of Pyruvate Depending on the oxidation state of the cell: Aerobic – converted to acetyl-CoA via TCA cycle.

KREBS CYCLE. Introduction Let us review fates of Pyruvate Depending on the oxidation state of the cell: Aerobic – converted to acetyl-CoA via TCA cycle.
Chapter 17 (Part 1) Amino Acid Metabolism: Nitrogen Assimilation and Amino Acid Biosynthesis.

Chapter 17 (Part 1) Amino Acid Metabolism: Nitrogen Assimilation and Amino Acid Biosynthesis.
Catabolic Pathways 2 nd Year Physiotherapy By Eman Mokbel Alissa, Ph.D.

Catabolic Pathways 2 nd Year Physiotherapy By Eman Mokbel Alissa, Ph.D.
1. 2 3 4 Fig. 3-12. Remember the function of the mitochondria? Look at the “enzymes” on the inner mitochondrial membrane. These are the cytochromes.

Fig Remember the function of the mitochondria? Look at the “enzymes” on the inner mitochondrial membrane. These are the cytochromes.
Amino Acid Metabolism. Essential Amino Acids Essential amino acids must be consumed in the diet. Mammalian cells lack enzymes to synthesize their carbon.

Amino Acid Metabolism. Essential Amino Acids Essential amino acids must be consumed in the diet. Mammalian cells lack enzymes to synthesize their carbon.
Oxidative Decarboxylation of pyruvate and TCA cycle

Oxidative Decarboxylation of pyruvate and TCA cycle
Introduction of Glucose Metabolism Lecture-4 GLUCONEOGENESIS GLUCONEOGENESIS.

Introduction of Glucose Metabolism Lecture-4 GLUCONEOGENESIS GLUCONEOGENESIS.
Citric acid cycle Krebs cycle, tricarboxylic acid cycle TCA The central function is the oxidation of acetyl CoA to CO2 - It is the final common pathway.

Citric acid cycle Krebs cycle, tricarboxylic acid cycle TCA The central function is the oxidation of acetyl CoA to CO2 - It is the final common pathway.
DENTAL BIOCHEMISTRY 2015 LECTURE 13 METABOLIC COMPARTMENTATION Michael Lea.

DENTAL BIOCHEMISTRY 2015 LECTURE 13 METABOLIC COMPARTMENTATION Michael Lea.
Oxidative Decarboxylation of Pyruvate

Oxidative Decarboxylation of Pyruvate
Biochemistry Lecture 11. Common Biochemical Reaction Types.

Biochemistry Lecture 11. Common Biochemical Reaction Types.
NITROGEN METABOLISM. animals plants fungi Nitrogen is essential for all organisms (in amino acids and nucleic acids). Most of the conversions between.

NITROGEN METABOLISM. animals plants fungi Nitrogen is essential for all organisms (in amino acids and nucleic acids). Most of the conversions between.
S TAGES OF A MINO A CIDS C ATABOLISM Dr. Samah Kotb Lecturer of Biochemistry 2015 Cellular Biochemistry and metabolism 2 CLS 333.

S TAGES OF A MINO A CIDS C ATABOLISM Dr. Samah Kotb Lecturer of Biochemistry 2015 Cellular Biochemistry and metabolism 2 CLS 333.
More about proteins Proteins are the building block of our bodies. They make up many components (muscle, skin) or direct the synthesis of components (bone,

More about proteins Proteins are the building block of our bodies. They make up many components (muscle, skin) or direct the synthesis of components (bone,
Oxidative Decarboxylation of pyruvate and TCA cycle

Oxidative Decarboxylation of pyruvate and TCA cycle
CHAPTER 5. Microbial Metabolism Metabolism- collection of controlled biochemical reactions in microbes 8 Elementary Statements – Acquires nutrients –

CHAPTER 5. Microbial Metabolism Metabolism- collection of controlled biochemical reactions in microbes 8 Elementary Statements – Acquires nutrients –
Oxidative Decarboxylation of pyruvate and TCA cycle

Oxidative Decarboxylation of pyruvate and TCA cycle
Genome-wide Responses to Mitochondrial Dysfunction

Genome-wide Responses to Mitochondrial Dysfunction

Similar presentations

Ads by Google