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Dramatic Response to Low-Dose Erlotinib of Epidermal Growth Factor Receptor Mutation-Positive Recurrent Non-small Cell Lung Cancer After Severe Cutaneous.

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Presentation on theme: "Dramatic Response to Low-Dose Erlotinib of Epidermal Growth Factor Receptor Mutation-Positive Recurrent Non-small Cell Lung Cancer After Severe Cutaneous."— Presentation transcript:

1 Dramatic Response to Low-Dose Erlotinib of Epidermal Growth Factor Receptor Mutation-Positive Recurrent Non-small Cell Lung Cancer After Severe Cutaneous Toxicity  Joline S.W. Lind, MBBS, MA, Pieter E. Postmus, MD, PhD, Daniëlle A.M. Heideman, MD, PhD, Erik B. Thunnissen, MD, PhD, Otto Bekers, MD, PhD, Egbert F. Smit, MD, PhD  Journal of Thoracic Oncology  Volume 4, Issue 12, Pages (December 2009) DOI: /JTO.0b013e3181bbb2b9 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Photography images of the face show a severe (grade 4) erlotinib-induced papulopustular rash on erlotinib 150 mg/d (A), which improved to grade 2 on erlotinib 50 mg/d (B). Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181bbb2b9) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Radiologic images before and 6 weeks after erlotinib 50 mg/d. Axial, contrast-enhanced computed tomographic (CT) images of the lungs show a right-sided pleural effusion and multiple intrapulmonary metastases bilaterally (arrows) (A), which shrunk or disappeared after 6 weeks of treatment (B). Axial, contrast-enhanced CT images of the abdomen show two liver metastases (arrows) (C), which decreased significantly in size (D). Journal of Thoracic Oncology 2009 4, DOI: ( /JTO.0b013e3181bbb2b9) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

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