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Single-dose extended-release oral azithromycin vs

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Presentation on theme: "Single-dose extended-release oral azithromycin vs"— Presentation transcript:

1 Single-dose extended-release oral azithromycin vs
Single-dose extended-release oral azithromycin vs. 3-day azithromycin for the treatment of group A β-haemolytic streptococcal pharyngitis/tonsillitis in adults and adolescents: a double-blind, double-dummy study  D.M. Jorgensen  Clinical Microbiology and Infection  Volume 15, Issue 12, Pages (December 2009) DOI: /j x Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 CONSORT flow diagram for the double-blind, double-dummy study evaluating the azithromycin extended-release formulation (AZ-ER) vs. the immediate-release formulation (AZ-IR). TOC, test-of-cure; BPP, bacteriological per-protocol population; LTFU, long-term follow-up; GABHS, group A β-haemolytic streptococcus. Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Rates of (a) bacteriological eradication and (b) clinical cure at test-of-cure (TOC) and continued at long-term follow-up (LTFU) in those subjects with eradication at the TOC visit and cured at the TOC visit, respectively (bacteriological per-protocol population). AZ-ER, azithromycin extended-release formulation; AZ-IR, azithromycin immediate-release formulation. [For the LTFU analyses, evaluable subjects in the bacteriologic per-protocol population also had to be classified as having bacteriological eradication at the TOC visit. Similarly, in Figure 2b, the LTFU evaluable subjects in the bacteriological per-protocol population also had to be classified as having a clinical cure at the TOC visit.] Clinical Microbiology and Infection  , DOI: ( /j x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions


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