Download presentation
Presentation is loading. Please wait.
Published byJan van der Meer Modified over 6 years ago
1
Effects of vasopressin on cardiac output and its distribution in the subhuman primate
John C. Kerr, B.S., Krishna M. Jain, M.D., Kenneth G. Swan, M.D., Joyce M. Rocko, M.D. Journal of Vascular Surgery Volume 2, Issue 3, Pages (May 1985) DOI: / (85) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions
2
Fig. 1 Effects of intravenous bolus injections of vasopressin on cardiac output and arterial pressure in subhuman primates. Log dose is expressed along abscissa in units kg−1, and the resultant changes in cardiac output (open circles) in ml min−1 and arterial pressure (closed circles) in mm Hg are expressed along ordinates. Each point on graph represents mean ± SEM of six experiments in six rhesus monkeys. Journal of Vascular Surgery 1985 2, DOI: ( / (85) ) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions
3
Fig. 2 Effects of 10-minute infusions of vasopressin at rates of 5 × 10−2 and 5 × 10−3 units kg−1 min−1 on superior mesenteric arterial blood flow, measured electromagnetically. Superior mesenteric arterial blood flow in ml min−1 is presented on ordinate and time in minutes is presented on abscissa. Infusions were begun at time zero and ended at minute 10. Each point on graph represents means of four experiments in four animals. Journal of Vascular Surgery 1985 2, DOI: ( / (85) ) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions
4
Fig. 3 Effects of 10-minute intravenous infusion of vasopressin on subhuman primate hemodynamics. Time course of experiment is presented along the abscissa in minutes. Infusion of vasopressin at rate of 5 × 10−3 units kg−1 min−1 was begun at time zero and continued for 10 minutes. On the ordinate, cardiac output is expressed in ml min−1, arterial pressure in mm Hg, total peripheral resistance in peripheral resistance units (PRU), and heart rate in beats min−1(bpm). Each point on graph represents mean ± SEM of six experiments in six rhesus monkeys. Journal of Vascular Surgery 1985 2, DOI: ( / (85) ) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions
5
Fig. 4 Effects of 10-minute intravenous infusions of vasopressin on subhuman primate hemodynamics. Time course of experiment is presented along the abscissa in minutes. Infusion of vasopressin at rate of 5 × 10−2 units kg−1 min−1 was begun at time zero and continued for 10 minutes. On the ordinate, cardiac output is expressed in ml min−1, arterial pressure in mm Hg, total peripheral resistance in peripheral resistance units (PRU), and heart rate in beats min−1 (bpm). Each point on the graph represents mean ± SEM of six experiments in six rhesus monkeys. Journal of Vascular Surgery 1985 2, DOI: ( / (85) ) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions
6
Fig. 5 Effects of intravenous vasopressin infusion at rate of 5 × 10−3 units kg−1 min−1 on distribution of cardiac output to splanchnic viscera as determined by radioactive microspheres. Vertical bars represent blood flow in ml min−1 during control period (cross-hatched) and at ninth minute of 10-minute infusion (striped) of vasopressin to various splanchnic organs. Each bar on graph represents mean ± SEM of six experiments in six animals. Parenthetical values along bottom of figure represent blood flow in terms of ml min−1 100 gm−1 of tissue during control period. Asterisks represent statistically significant differences between control values and during vasopressin infusion (* = p < 0.05 and ** = p < 0.02). Journal of Vascular Surgery 1985 2, DOI: ( / (85) ) Copyright © 1985 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.