1. Description of the design of three recent phase III clinical trials incorporating fluoroquinolone antibiotics in treatment-shortening regimens for pulmonary tuberculosis: REMoxTB [9], RIFAQUIN [10] and OFLOTUB [11].
Description of the design of three recent phase III clinical trials incorporating fluoroquinolone antibiotics in treatment-shortening regimens for pulmonary tuberculosis: REMoxTB [9], RIFAQUIN [10] and OFLOTUB [11]. Note that moxifloxacin/rifapentine 900 mg was administered twice weekly and moxifloxacin/rifapentine 1200 mg was administered weekly. H: isoniazid; R: rifampicin; Z: pyrazinamide; E: ethambutol; M: moxifloxacin; Rp: rifapentine (with a subscript defining dose); G: gatifloxacin; ep, mp, rp and hp: placebos for ethambutol, moxifloxacin, rifampicin and isoniazid, respectively; LJ: Lowenstein–Jensen; MGIT: Mycobacteria Growth Indicator Tube.
Stephen H. Gillespie Eur Respir Rev 2016;25:19-28
©2016 by European Respiratory Society