Presentation is loading. Please wait.

Presentation is loading. Please wait.

Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular.

Published byCorey Stephens Modified over 6 years ago

Similar presentations

Presentation on theme: "Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular."— Presentation transcript:

1 Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular treatment of lower extremity peripheral arterial disease  Baolei Guo, MD, Qiwen Tan, MSc, Daqiao Guo, MD, Zhenyu Shi, MD, Chunyan Zhang, MSc, Wei Guo, MSc  Journal of Vascular Surgery  Volume 60, Issue 4, Pages (October 2014) DOI: /j.jvs Copyright © Terms and Conditions

2 Fig 1 Box and whisker plot shows the clopidogrel response in the enrolled patients, as assessed by platelet mapping assay in response to 20 μmol/L of adenosine diphosphate (ADP) after a stable administration of clopidogrel. The horizontal line within each box represents the median, and the lower and upper borders of each box represent the 25th and the 75th percentiles, respectively, and the whiskers mark the 95% confidence intervals. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

3 Fig 2 Kaplan-Meier curve shows primary vessel patency during follow-up in patients with and without the cytochrome P450 (CYP) 2C19 loss-of-function (LOF) allele (n = 50). P = .006 by log-rank test. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

4 Fig 3 Estimated rates of primary end points are shown according to platelet reactivity characteristics (n = 50). P = .012 by log-rank test. HPR, High platelet reactivity; NPR, normal platelet reactivity. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © Terms and Conditions

Download ppt "Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular."

Similar presentations

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease  Joseph P. Archie, PhD, MD  Journal of Vascular.

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease  Joseph P. Archie, PhD, MD  Journal of Vascular.
The application of infrared thermography in evaluation of patients at high risk for lower extremity peripheral arterial disease  Chi-Lun Huang, MD, Yen-Wen.

The application of infrared thermography in evaluation of patients at high risk for lower extremity peripheral arterial disease  Chi-Lun Huang, MD, Yen-Wen.
The application of infrared thermography in evaluation of patients at high risk for lower extremity peripheral arterial disease  Chi-Lun Huang, MD, Yen-Wen.

The application of infrared thermography in evaluation of patients at high risk for lower extremity peripheral arterial disease  Chi-Lun Huang, MD, Yen-Wen.
Surgical outcomes of vascular reconstruction in soft tissue sarcomas of the lower extremities  Kenji Nishinari, MD, PhD, Mariana Krutman, MD, Samuel Aguiar.

Surgical outcomes of vascular reconstruction in soft tissue sarcomas of the lower extremities  Kenji Nishinari, MD, PhD, Mariana Krutman, MD, Samuel Aguiar.
Randomized controlled trial of aspirin and clopidogrel versus aspirin and placebo on markers of smooth muscle proliferation before and after peripheral.

Randomized controlled trial of aspirin and clopidogrel versus aspirin and placebo on markers of smooth muscle proliferation before and after peripheral.
Endovascular therapy for acute limb ischemia

Endovascular therapy for acute limb ischemia
Restenosis in gold-coated renal artery stents

Restenosis in gold-coated renal artery stents
Balloon angioplasty versus Viabahn stent graft for treatment of failing or thrombosed prosthetic hemodialysis grafts  Thomas Vesely, MD, William DaVanzo,

Balloon angioplasty versus Viabahn stent graft for treatment of failing or thrombosed prosthetic hemodialysis grafts  Thomas Vesely, MD, William DaVanzo,
The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation  Jeroen Otte, MD, MSc, Jaap J. van Netten,

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation  Jeroen Otte, MD, MSc, Jaap J. van Netten,
Skills training after night shift work enables acquisition of endovascular technical skills on a virtual reality simulator  Peter A. Naughton, MD, Rajesh.

Skills training after night shift work enables acquisition of endovascular technical skills on a virtual reality simulator  Peter A. Naughton, MD, Rajesh.
Jason W. Christie, MD, Thomas D. Conlee, MD, Timothy E

Jason W. Christie, MD, Thomas D. Conlee, MD, Timothy E
Mortality rates and mortality predictors in patients with symptomatic peripheral artery disease stratified according to age and diabetes  Thomas Mueller,

Mortality rates and mortality predictors in patients with symptomatic peripheral artery disease stratified according to age and diabetes  Thomas Mueller,
A comparison of covered vs bare expandable stents for the treatment of aortoiliac occlusive disease  Bibombe P. Mwipatayi, MMed (Surg), FCS (SA), FRACS,

A comparison of covered vs bare expandable stents for the treatment of aortoiliac occlusive disease  Bibombe P. Mwipatayi, MMed (Surg), FCS (SA), FRACS,
Vein harvesting technique for infrainguinal arterial bypass with great saphenous vein and its association with surgical site infection and graft patency 

Vein harvesting technique for infrainguinal arterial bypass with great saphenous vein and its association with surgical site infection and graft patency 
Frequency of cancer in patients operated on for acute peripheral arterial thrombosis and the impact on prognosis  Chalotte Winther Nicolajsen, MD, Maja.

Frequency of cancer in patients operated on for acute peripheral arterial thrombosis and the impact on prognosis  Chalotte Winther Nicolajsen, MD, Maja.
The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation  Jeroen Otte, MD, MSc, Jaap J. van Netten,

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation  Jeroen Otte, MD, MSc, Jaap J. van Netten,
Impact of diabetes mellitus on outcomes of superficial femoral artery endoluminal interventions  Andrew M. Bakken, MD, Eugene Palchik, MD, Joseph P. Hart,

Impact of diabetes mellitus on outcomes of superficial femoral artery endoluminal interventions  Andrew M. Bakken, MD, Eugene Palchik, MD, Joseph P. Hart,
Mark G. Davies, MD, PhD, MBA, Wael E. Saad, MD, Jean X

Mark G. Davies, MD, PhD, MBA, Wael E. Saad, MD, Jean X
Adjunctive use of the superficial femoral vein for vascular reconstructions  Soma Brahmanandam, MD, MPH, Daniel Clair, MD, James Bena, MS, Timur Sarac,

Adjunctive use of the superficial femoral vein for vascular reconstructions  Soma Brahmanandam, MD, MPH, Daniel Clair, MD, James Bena, MS, Timur Sarac,
A randomized phase II study of Xilonix, a targeted therapy against interleukin 1α, for the prevention of superficial femoral artery restenosis after percutaneous.

A randomized phase II study of Xilonix, a targeted therapy against interleukin 1α, for the prevention of superficial femoral artery restenosis after percutaneous.

Similar presentations

Ads by Google