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Fig. 4. Liver HBV mRNA paired-end sequencing reads in HBeAg-positive and HBeAg-negative chimpanzees.
Liver HBV mRNA paired-end sequencing reads in HBeAg-positive and HBeAg-negative chimpanzees. The HBV mRNA and HBV protein open reading frames are positioned relative to the coordinates of the HBV genome. The mRNA-seq read histograms are shown for HBeAg-positive chimpanzees 4x0139, A2A004, A3A006, and A4A014; for HBeAg transitional chimpanzee 89A008; and for HBeAg-negative chimpanzees 88A010, 95A010, and 95A008. Locations of the DR1 sequence (red line), HBV PAS (brown dashed line), and binding sites for the siRNAs in ARC-520 (siHBV-74 and siHBV-77) are indicated. Christine I. Wooddell et al., Sci Transl Med 2017;9:eaan0241 Published by AAAS
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