1. Predictive Low Glucose Suspend (PLGS)

2. Severe Hypoglycemia in People With T1D

3. How Can Hypoglycemia Be Prevented?

4. Suspending Insulin for Hypoglycemia Prevention and Avoidance: The Automated Insulin Roadmap

5. The Beginnings: Low Glucose Suspend (LGS)

6. PLGS: 12 Years of Evolution

7. What Is PLGS?

8. Early PLGS Studies Inpatient (2008-2010)

9. Further PLGS Studies Outpatient (2013-2015)

10. PLGS Reduces Nocturnal Hypoglycemia

11. Medtronic Study (2016)

12. Tandem PLGS (Basal-IQ™) Inpatient Feasibility Study

13. Tandem PLGS Linear Regression Algorithm

14. Tandem PLGS Inpatient Feasibility Study Outcomes

15. Tandem PLGS Inpatient Feasibility Study

16. PLGS Patient Example

17. Tandem PLGS Feasibility Study Results

18. Tandem Basal-IQ™ Pivotal PROLOG Trial

19. PROLOG Trial Design

20. PROLOG Trial Primary Outcome Time < 70 mg/dL (3.9 mmol/L)

21. PROLOG Trial Median Time < 70 mg/dL During Day and Night

22. PROLOG Trial Primary Outcome

23. PROLOG Trial Safety

24. Enhancing Patient Care With PLGS Clinical Pearl #1: Set Expectations

25. System Usability Questionnaire (SUS)

26. Enhancing Patient Care With PLGS Clinical Pearl #2: Alert Settings Are Actionable

27. Enhancing Patient Care With PLGS Clinical Pearl #3: Treating Hypoglycemia

28. Conclusions and Key Takeaways

29. Conclusions and Key Takeaways (cont)

30. Conclusions and Key Takeaways (cont)

31. Abbreviations