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Never Underestimate the Power of a Neutrophil

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1 Never Underestimate the Power of a Neutrophil
Marco A. Cassatella, Massimo Locati, Alberto Mantovani  Immunity  Volume 31, Issue 5, Pages (November 2009) DOI: /j.immuni Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Pattern Recognition and Regulatory Function of Neutrophils
Classically, PMN interaction with pathogens triggers a number of effector functions promoting inflammation. The findings by Lo-Man and colleagues demonstrate that in murine PMN a Syk-MyD88-dependent pathway activated by concomitant engagement of C-type lectin receptors (CLRs) and Toll-like receptors (TLRs) induces production of large amounts of the anti-inflammatory cytokine IL-10 exerting immunoregulatory functions. Immunity  , DOI: ( /j.immuni ) Copyright © 2009 Elsevier Inc. Terms and Conditions


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