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Diabetes: Introduction
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OUTLINE Insulin and Sugar (Glucose) Symptoms and Reasons
Logics and Tips to Apply
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Glucose is the currency of body & every cell needs it
Type 2 Type 1
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Type 2 DM
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Type 1 Type 2 Defects in Diabetes Zero Insulin Less Insulin
Lost Identity Type 1 Type 2
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Cont. Progressive Disorder Weakness Weight Loss Excessive Hunger
Excessive Thirst Progressive Disorder
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Simple Logics and Application agents
Insulin secretion Pancreas Carbohydrate breakdown/ absorption Intestine -glucosidase inhibitors (e.g. acarbose) – delay digestion and absorption of carbohydrates in the gastrointestinal tract.1,2 Sulfonylureas and meglitinides – stimulate insulin secretion from the pancreas.1,2 Biguanides (e.g. metformin) – suppress liver glucose output, enhance insulin sensitivity in the liver and stimulate insulin-mediated glucose disposal. They do not stimulate insulin secretion.1,2 Thiazolidinediones – decrease insulin resistance in fat, muscle and liver. In addition, they improve estimates of -cell function.1,2 1Kobayashi M. Diabetes Obes Metab 1999; 1 (Suppl. 1):S32–S40. 2Nattrass M & Bailey CJ. Baillieres Best Pract Res Clin Endocrinol Metab 1999; 13:309–329. Insulin resistance Kobayashi M. Diabetes Obes Metab 1999; 1 (Suppl. 1):S32–S40. Nattrass M & Bailey CJ. Baillieres Best Pract Res Clin Endocrinol Metab 1999; 13:309–329.
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Sulfonylureas/ meglitinides
Diet Pattern Insulin secretion Sulfonylureas/ meglitinides Divided Meals Small Eating (Portion Size) Preserve Pancreas from Over-exertion
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Carbohydrate breakdown/ absorption -glucosidase inhibitors
Type of Carbohydrates Carbohydrate breakdown/ absorption -glucosidase inhibitors Complex Carbs (More of Fibre) Reduced Absorption Better Glycemic Control alongwith Satiety
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Tips to Patient More Vegetables Fruits (portion size) Avoid Juices
Slow Eating (Better Satiety) Consumption of Water and Buttermilk b/w Meals
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Insuiln Sensitivity More Fibres Watch on Fat Consumption
Insulin resistance Thiazolidinediones More Fibres Watch on Fat Consumption Active Daily Life Individualized Approaches for Exercise Plan
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Need of Hour Protect Those Who Makes Genuine Mistakes.
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