1. Mechanisms of Neuronal Degeneration in Alzheimer's Disease
Bruce A. Yankner 
Neuron 
Volume 16, Issue 5, Pages (May 1996)
DOI: /S (00)

2. Figure 1 Inherited Mutations That Cause AD
(A) APP. Sites of inherited mutations surrounding or within the Aβ domain are shown with asterisks. The mutations either increase Aβ production, alter the length of Aβ, or increase Aβ aggregation.
(B) The seven transmembrane domain protein S182. Shown are the sites of five inherited mutations in S182 and a mutation in the homologous protein STM2. Five of the six mutations are proximal to a transmembrane domain.
Neuron  , DOI: ( /S (00) )

3. Figure 2 Aβ Fibril Formation and Potential Mechanisms of Neurotoxicity
Age-related factors or inherited mutations induce the formation of Aβ fibrils, which may cause neuronal degeneration through several potential cellular mechanisms.
Neuron  , DOI: ( /S (00) )

4. Figure 3 Potential Pathogenic Mechanisms Involving ApoE
Individuals carrying the E4 allele of ApoE are at increased risk of developing AD. The E3 and E4 alleles may differentially affect Aβ fibril formation, tau phosphorylation, or cholesterol transport involved in neurite outgrowth and synaptogenesis.
Neuron  , DOI: ( /S (00) )