1. Hormone Receptor-Positive Advanced Breast Cancer: Will ESR1 Have a Role?

2. Breast Cancer Statistics

3. Endocrine Sensitivity vs Resistance

4. ER+ Advanced Breast Cancer Treatment Options

5. Molecular Mechanism of Endocrine Resistance

6. TAnDEM: Anastrozole+/-Trastuzumab

7. ESR1 Mutations

8. Endocrine Resistance Diagnostic Measures to Identify Mutations

9. Detection of ESR1 Mutations Advantages of cfDNA Analysis

10. BOLERO-2 Secondary Analysis: Prevalence of ESR1 Mutations in cfDNA of Pts with MBC

11. BOLERO-2 Secondary Analysis Effect of ESR1 Mutations on OS

12. BOLERO-2 Secondary Analysis Effect of ESR1 Mutations on PFS

13. PALOMA3: ESR1 Mutations in Treatment of ER+ MBC

14. PFS in PALOMA3 by ESR1 Mutation Status

15. SoFEA: ESR1 Mutations in Treatment of ER+ MBC

17. Concluding Remarks

18. Abbreviations

19. Abbreviations