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The pharmacokinetics and toxicity of morning vs

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1 The pharmacokinetics and toxicity of morning vs
The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison  A.P. Prayle, K. Jain, D.J. Touw, B.C.P. Koch, A.J. Knox, A. Watson, A.R. Smyth  Journal of Cystic Fibrosis  Volume 15, Issue 4, Pages (July 2016) DOI: /j.jcf Copyright © Terms and Conditions

2 Journal of Cystic Fibrosis 2016 15, 510-517DOI: (10. 1016/j. jcf. 2015
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3 Fig. 1 Consort diagram of included participants.
Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions

4 Fig. 2 Increase in urinary KIM1 evening versus morning administration group. Urinary KIM1 was collected at the start and end of therapy. Lines represent the mean and standard error of the mean. Levels were normalised to urinary creatinine to control for urinary concentration (ng KIM1 per mg creatinine). Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions

5 Fig. 3 Melatonin profiles.
Each plot represents the profile for an individual participant. Purple background (a–g): normal; Yellow Background (h–k): abnormal. For definitions of normal and abnormal, please see methods. Journal of Cystic Fibrosis  , DOI: ( /j.jcf ) Copyright © Terms and Conditions


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