1. No Conflict of Interest to Declare Sufia Dadabhai, PhD MHS Johns Hopkins Bloomberg School of Public Health Blantyre, Malawi

2. Pregnancy Outcomes and Infant Survival in the Era of Universal HAART in Africa (POISE)
What we know: HAART nearly eliminates MTCT of HIV What we do not know: Impact on adverse pregnancy outcomes Methods: Prospectively compare PTB, LBW and survival in infants born to ART-experienced women vs. HIV-uninfected women in Blantyre, Malawi Enrolled at delivery between Jan 2016 and June 2017: 677 HIV+ (75% VL suppressed) and 469 HIV- mother infant pairs
Malawi first line: : tenofovir, lamuvidine, efavirenz

3. Risk of Pre-term Birth in POISE by Time of HAART Initiation
Key Finding # 1: No significant differences observed in PTB or LBW between ART-exposed and unexposed infants
LBW: Exposed 6.8%, Unexposed 5.0% (p=0.20) PTB: Exposed11.3%, Unexposed 9.6% (p=0.37)
Risk of Pre-term Birth in POISE by Time of HAART Initiation
HAART Initiation
PTB Observed
p for trend N %
1st Trimester
5/72
6.9%
0.85
2nd Trimester
12/144
8.3%
3rd Trimester
8/48
16.7%
Before conception
28/205
13.7%

4. Key Finding # 2: Mortality and MTCT of HIV are still significant public health concerns
5 infants known to be HIV-infected
To date, 7 infants died
4 HIV-exposed
3 HIV-unexposed.
One HIV-infected women died
Conclusion: Reassuring; HAART can reduce MTCT of HIV without negative impact on other pregnancy outcomes