1. به نام خالق زیبایی ها
Hormone 2
Dr.Radmanesh

2. Pituitary Gland and Hypothalamus

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© 2005 Elsevier

6. Anterior Pituitary continued
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© 2005 Elsevier

9. Anterior Pituitary
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© 2005 Elsevier

19. dr. Radmanesh

21. Hypothalamus, Posterior Pituitary and Target Tissues

24. Control of ADH Secretion

25. Action : V1 receptor: constriction of blood
vessel increase in blood pressure.
V2 receptor: reabsorption of H2O
from collecting duct.
Dehydration, hemorrhage:↑ADH
dr. Radmanesh

26. Dr. Bolliger Kanas University Medical Center 1999
The basic feedback loop is shown in this slide. An increase in ECF osmolality stimulates the osmoreceptive cells in the two hypothalmic nuclei. The cell bodies of these neurons respond to stretch and their firing rate is directly proportional to it.
As we will see soon, these neuroendocrine cells are also innervated by nerve tracks coming from the medulla. These nerve tracks receive input from the baroreceptors in and around the great vessels of the heart.
When firing rate of the neuroendocrine cells increase, ADH is released from the post synaptic nerve terminals in the posteriour pituitary. The half life of ADH is only about 20 min. This allows the effect of the hormone to be rapidly present and rapidly cease when it is no longer needed. This is a very tightly regulated hormone. The figure implies that ADH acts on the CCD and Medullary collecting ducts to increase water reaborption. As ADH levels increase, urine volume decreases and urine osmolality increases.
Dr. Bolliger Kanas University Medical Center 1999
dr. Radmanesh

27. The Effects of ADH on the distal collecting tubules and Collecting Ducts
dr. Radmanesh
Figure 26.15a, b

28. Formation of Water Pores: Mechanism of Vasopressin Action
dr. Radmanesh

29. Facultative water reabsorption
dr. Radmanesh

30. dr. Radmanesh

33. Control of Oxytocin Secretion

34. Fig 11.13
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37. Metabolic Action of Growth Hormone
Figure 16.6

38. Regulation of GH Secretion

39. Feedback Control of Anterior Pituitary
Fig 11.17
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