1. Some powerpoint slides shown during CHEM 641 class 9/12/07
Primary sequence
Human hemoglobin beta-subunit (FASTA format)
>gi| |ref|NP_ | beta globin [Homo sapiens] MVHLTPEEKSAVTALWGKVNVDEVGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVAN ALAHKYH

2. Primary Sequence Secondary Structure
a-helix

3. Secondary Structure Tertiary Structure

4. Tertiary Structure Quaternary Structure
ht-ADH from
B. stearothermophilus
is a homotetramer

5. Hemoglobin and Myoglobin Quaternary Structure
Hb 22-heterotetramer
Mb – single subunit (tertiary structure only)
Click picture
to right for Hb dynamics movie

6. Classes of Globular Protein Folds
Anti-parallel a-helix
Parallel b-sheet b-a-b motif
Anti-parallel b-sheet
Metal / disulfide rich