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John W. Steinke, PhD, Spencer C. Payne, MD, M

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Presentation on theme: "John W. Steinke, PhD, Spencer C. Payne, MD, M"— Presentation transcript:

1 Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis 
John W. Steinke, PhD, Spencer C. Payne, MD, M. Elizabeth Tessier, MD, Lori O. Borish, RN, Joseph K. Han, MD, Larry C. Borish, MD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 6, Pages e7 (December 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Change in CT score after budesonide nasal irrigation. Each dot represents an individual with a line connecting the prebudesonide and postbudesonide CT scores. The bold lines to the side of the data points indicate the median, with the interquartile range and inner fence indicated with a box and whisker plot, respectively (P < .05 for prebudesonide compared with postbudesonide sinus score). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Self-assessed change in sinus symptom score after budesonide nasal irrigation. Each dot represents an individual, with a line connecting the prebudesonide and postbudesonide sinus scores. Lines to the side of the data points indicate the mean ± SEM (P < .01 for prebudesonide compared with postbudesonide sinus score). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 VAS for sinus symptoms. Each subject was asked to rate each of 16 symptoms. The range of symptoms was none to severe. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Patient perception of sense of smell after budesonide nasal irrigation
Patient perception of sense of smell after budesonide nasal irrigation. Using a VAS, subjects were asked to assess their sense of smell before and after nasal irrigation. The VAS was converted to a digital scale rated 0 (no smell) to 6 (no impairment in ability to smell). Each dot represents an individual with a line connecting the prebudesonide and postbudesonide scores, and the lines to the side of the data points indicate the means ± SEMs (P <.05 for prebudesonide compared with postbudesonide sense of smell). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Endoscopic scoring system. Modified from Lund VJ, Kennedy DW
Endoscopic scoring system. Modified from Lund VJ, Kennedy DW. Staging for rhinosinusitis. Otolaryngol Head Neck Surg 1997;117:S35-S40.E7 Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 VAS for asthma symptoms
VAS for asthma symptoms. Each subject was asked to rate each of 6 symptoms. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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