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A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis  N.L.D. Smith, J. Hankinson, A. Simpson, P.

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Presentation on theme: "A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis  N.L.D. Smith, J. Hankinson, A. Simpson, P."— Presentation transcript:

1 A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis  N.L.D. Smith, J. Hankinson, A. Simpson, P. Bowyer, D.W. Denning  Clinical Microbiology and Infection  Volume 20, Issue 8, Pages O480-O488 (August 2014) DOI: / Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1 Expression of the IL1 pathway differs between MDMs from CCPA (open circles) and healthy subjects (closed squares). Fold difference is calculated relative to the healthy 0 h. p-values indicate the differences in the change over time between the two groups, calculated by repeated measures two-way ANOVA. Each group comprises ten pooled RNA samples. Mean and standard deviations are shown for the three replicates completed. Clinical Microbiology and Infection  , O480-O488DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2 Genotype frequencies of SNPs associated with CCPA; 279 healthy subjects and 112 CCPA subjects were genotyped successfully. RS is an insertion-deletion mutation. Clinical Microbiology and Infection  , O480-O488DOI: ( / ) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions


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