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CLASSIFICATION OF ANEMIAS
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LEARNING OBJECTIVE CLASSIFY ANAEMIAS
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Chronic: GIT lesions,gynaecological disturbances
1. BLOOD LOSS Acute: trauma Chronic: GIT lesions,gynaecological disturbances 2. INCREASED RATE OF RED CELL DESTRUCTION INTRINSIC ABNORMALITIES OF RED CELLS Red cell membrane disorders Hereditary spherocytosis Red cell enzyme deficiences G6PD deficiency
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Disorders of haemoglobin synthesis
Quantitative defect of globin synthesis- Thalassemias Qualitative defect of globin synthesis - Sickle cell anaemia EXTRINSIC ABNORMALITIES OF RED CELLS Antibody mediated transfusion reactions Idiopathic Drug induced
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Mechanical trauma to red cells Microangiopathic hemolytic anaemia
Thrombotic thrombocytopenia purpura DIC Severe vasculitis CHEMICAL INJURY Lead poisoning
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3.IMPAIRED RED CELL PRODUCTION
DISTURBANCE OF PROLIFERATION OF RED CELLS Aplastic anaemia DISTURBANCE OF MATURATION OF ERYTHROBLAST Defective DNA Synthesis -Vitamin B12 and folate Defective hemoglobin synthesis Deficient heme synthesis- Iron deficiency anaemia Deficient globin synthesis - Thalassemias
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MATERIALS AND METHODS 50 patients of ALL
SAMPLE SIZE 50 patients of ALL SAMPLING TECHNIQUE Non probability purposive sampling
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SPECIMEN COLLECTION Three ml venous blood in EDTA
Bone marrow aspirate in EDTA Bone marrow aspiration smears Genomic DNA was extracted from blood/bone marrow
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