1. Endocan as a potential diagnostic or prognostic biomarker for chronic kidney disease 
Hyun Gyu Lee, Hoon Young Choi, Jong-Sup Bae 
Kidney International 
Volume 86, Issue 6, Pages (December 2014)
DOI: /ki
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2. Figure 1
The regulation mechanism of endocan expression. VEGF-induced endocan expression is regulated by PKC/NFKB (positive) and PI3K/AKT/FKHRL1 (negative) signaling pathways. The balance of two signaling pathways influences ESM-1 promoter activities. (Hypothesis) The ESM-1 promoter is methylated in most tissues. During cancer progression or systemic inflammation, demethylation of CpG islands in the ESM-1 promoter allows HIF-1α to bind the HIF-1α response element (HRE).
Kidney International  , DOI: ( /ki )
Copyright © 2014 International Society of Nephrology Terms and Conditions