1. Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function 
Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn R Gaudette, MSc, Irvin B Krukenkamp, MD 
The Annals of Thoracic Surgery 
Volume 68, Issue 3, Pages (September 1999)
DOI: /S (99)

2. Fig 1
Schematic diagram of experimental protocol. Hearts were subdivided into groups receiving one of the five preconditioning stimuli shown. Control hearts did not receive any stimulus before regional ischemia. (l-NAME = NG-nitro-l-arginine methyl ester; IPC = ischemic preconditioning; LAD = left anterior descending coronary artery.)
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3. Fig 2
Left ventricular end-diastolic pressure. Ischemic preconditioning (IPC) or drug infusion occurred before 0 on the time line. Regional ischemia occurred from 0 to 60 minutes, and reperfusion from 60 to 120 minutes. Data are shown as mean ± SEM. (l-NAME = NG-nitro-l-arginine methyl ester; LARG = l-arginine; ESM = esmolol; NIP = nipradilol.)
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

4. Fig 3
Left ventricular peak developed pressure. Peak developed pressure was defined as the difference between end-systolic pressure and end-diastolic pressure. Data are shown as mean ± SEM. ∗ = p < 0.05 versus control. See Figure 2 for abbreviations and events time table.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

5. Fig 4
Action potential duration at 50% repolarization (APD50). Data are shown as mean ± SEM. ∗ = p < 0.05 versus control. See Figure 2 for abbreviations and events time table.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

6. Fig 5
Infarct size for each heart is marked with an X. Bars indicate mean ± SEM for each group of hearts. Infarct sizes are based on the infarcted area as a percentage of the left ventricle at risk. ∗ = p < 0.05 versus control and l-NAME + l-arginine. See Figure 2 for abbreviations.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )

7. Fig 6
Coronary flow throughout the experiments. Data are shown as mean ± SEM. ∗ = p < 0.05 versus control and l-arginine. See Figure 2 for events time table.
The Annals of Thoracic Surgery  , DOI: ( /S (99) )