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Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled.

Published bySonny Atmadjaja Modified over 6 years ago

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Presentation on theme: "Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled."— Presentation transcript:

1 Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled trial  Mark D. Farrar, PhD, Raqib Huq, MB ChB, Sarah Mason, PhD, Anna Nicolaou, PhD, Kayleigh A. Clarke, PhD, Tristan P. Dew, PhD, Gary Williamson, PhD, Rachel E.B. Watson, PhD, Lesley E. Rhodes, MD  Journal of the American Academy of Dermatology  Volume 78, Issue 2, Pages (February 2018) DOI: /j.jaad Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Ultraviolet radiation (UVR)-induced cyclobutane pyrimidine dimers (CPD) in skin from a randomized, controlled study of 12 weeks of supplementation with green tea catechins and vitamin C versus placebo. Representative immunohistochemistry and quantification of CPD in UVR-exposed (3 × minimal erythema dose; MED) and unexposed skin at baseline and postsupplementation. Active n = 20 subjects, placebo n = 24 subjects. Scale bar = 50 μm. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Time course of ultraviolet radiation–induced cyclobutane pyrimidine dimers (CPD) in skin at baseline and after 4 weeks supplementation with green tea catechins and vitamin C. Data are mean + SD number of CPD-positive cells/1000 μm2 epidermis in unexposed skin (0 hours) and at 0.25, 6, and 24 hours after UVR exposure of skin. n = 5 subjects. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

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