1. Mean ADHD-RS-IV Scores at End Point30 25 20
Mean ADHD-RS-IV Total Score 15 10 5
Baseline 1 4 6 12 18 24
End point
Months
Placebo
Part A active treatment four-week double-blind study
Part B active treatment six-month open-label study
Adapted from Cutler A. APA 2007, Abstract NR654.

2. Patient improvement (%)
Improvements in CGI-I Scores 90 80 70 60 50
Patient improvement (%) 40 30 20 10 *
Month 1 4 6 12 18 24
End point
Double-blind phase
Open-label extension
Placebo part A
Active treatment part A
Active treatment part B
*No participants received placebo, hence value at 24 months is 0.
Adapted from Weisler R. APA 2007, Abstract NR650.

3. Mean Changes in Pulse and Heart Rate6
Mean pulse rate 5
Mean heart rate 4 3 2
Active treatment Part B
Pulse and heart rate (bpm) 1
Placebo
Part A
Active treatment Part A -1 -2 -3 -4
Double-blind
Open-label
All patients
Adapted from Weisler R. APA 2007, Abstract NR652.